Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization
نویسندگان
چکیده
منابع مشابه
Graphical Abstract Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization
Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously ob...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2007
ISSN: 0040-4020
DOI: 10.1016/j.tet.2007.06.103